| # | Title | Sep 25 - 27 | % Chg. | Theaters | Weeks | AVG | Cumulative | ||
| 1 | Cloudy With a Chance of Meatballs | $ 25,038,803 | -17.4 | 3,119 | 2 | $ 8,028 | $ 60,474,555 | ||
| 2 | Surrogates | 14,902,692 | 2,951 | 1 | 5,050 | 14,902,692 | |||
| 3 | Fame | 10,011,682 | 3,096 | 1 | 3,234 | 10,011,682 | |||
| 4 | The Informant! | 6,624,085 | -36.7 | 2,505 | 2 | 2,644 | 20,700,946 | ||
| 5 | I Can Do Bad All By Myself | 4,759,833 | -51.8 | 2,120 | 3 | 2,245 | 44,552,477 | ||
| 6 | Pandorum | 4,424,126 | 2,506 | 1 | 1,765 | 4,424,126 | |||
| 7 | Love Happens | 4,307,980 | -46.5 | 1,898 | 2 | 2,270 | 14,708,710 | ||
| 8 | Jennifer's Body | 3,664,559 | -46.6 | 2,738 | 2 | 1,338 | 12,470,373 | ||
| 9 | 9 | 2,959,231 | -46.8 | 2,025 | 3 | 1,461 | 27,227,811 | ||
| 10 | Inglourious Basterds | 2,683,198 | -29.7 | 1,960 | 6 | 1,369 | 114,420,733 |
Source: Box Office Guru
