| # | Title | Oct 2 - 4 | % Chg. | Theaters | Weeks | AVG | Cumulative | ||
| 1 | Zombieland | $ 24,733,155 | 3,036 | 1 | $ 8,147 | $ 24,733,155 | |||
| 2 | Cloudy With a Chance of Meatballs | 15,809,039 | -36.9 | 2,977 | 3 | 5,310 | 81,501,320 | ||
| 3 | Toy Story & Toy Story 2 (3D) | 12,491,789 | 1,745 | 1 | 7,159 | 12,491,789 | |||
| 4 | Surrogates | 7,241,054 | -51.4 | 2,951 | 2 | 2,454 | 26,284,134 | ||
| 5 | The Invention of Lying | 7,027,472 | 1,707 | 1 | 4,117 | 7,027,472 | |||
| 6 | Whip It | 4,650,812 | 1,721 | 1 | 2,702 | 4,650,812 | |||
| 7 | Fame | 4,626,952 | -53.8 | 3,133 | 2 | 1,477 | 16,507,188 | ||
| 8 | Capitalism: A Love Story | 4,447,378 | 962 | 2 | 4,623 | 4,849,067 | |||
| 9 | The Informant! | 3,689,235 | -44.3 | 2,425 | 3 | 1,521 | 26,469,331 | ||
| 10 | Love Happens | 2,749,025 | -36.2 | 1,922 | 3 | 1,430 | 18,882,080 |
Source: Box Office Guru
